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Mass production of uniform alginate capsules for micro cell encapslation using micro chamber array

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3 Author(s)
Kitagawa, H. ; Univ. of Tokyo, Tokyo ; Wei-heong Tan ; Takeuchi, S.

This work is motivated by the need for accurate positioning of both adherent and non-adherent cells into arrays that can be integrated with microfluidic channels in high-throughput screening (HTS) for drug discovery. We describe a microfluidic device that allows rapid production of uniform micro hydrogel capsules that can contain cells. Up to 1times104 hydrogel capsules can be simply formed and arrayed simultaneously using microchambers in a 10 mm long microchannel. In this work, alginate was used as the hydrogel capsules that can be dissolved and removed with EDTA; thus samples confined in the capsules are collectable after observation in the array. We demonstrated the microencapsulation of E. coli into alginate capsules, and dissolved the capsules with EDTA successfully.

Published in:

Micro Electro Mechanical Systems, 2007. MEMS. IEEE 20th International Conference on

Date of Conference:

21-25 Jan. 2007