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Prediction of protein interactions by combining genetic algorithm with SVM method

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5 Author(s)
Wang, Bing ; Anhui Univ. of Technol., Anhui ; Lu-sheng Ge ; Wen-You Jia ; Li Liu
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This paper proposes a novel hybrid GA/SVM method that can predict the interactions between proteins intermediated by the protein-domain relations. Firstly, we represented a protein by the domains contained inside, which can consider the effects of domain duplication. To simulate the combination of different domains, a transformation of the domain composition was taken subsequently. Further, a genetic algorithm was used to seek the optimized transformation, which had been adopted as the input vector of a predictor constructed using support vector machines method. Finally, experiment results validated the effectiveness and efficiency of our proposed approach by a better performance.

Published in:

Evolutionary Computation, 2007. CEC 2007. IEEE Congress on

Date of Conference:

25-28 Sept. 2007