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In this letter, variational models in pixel domain and wavelet domain are presented for fusion and denoising of noisy multifocus images. In pixel domain, the problem is formulized as minimizing a weighted energy functional, where the total variation (TV) is used as regularity constraint for noise reduction. A new family of weight functions for fusion is proposed that are based on the local average modulus of gradients and the power transform. In wavelet domain, the problem is formulized as shrinkage of the weighted wavelet coefficients of source images, where weight functions are based on the local average modulus of intra- and inter-scale wavelet coefficients and the power transform. The experiments are made to verify the effectiveness of the proposed methods.