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Motion artifact is a common occurrence that contaminates physiologic measurements such as pulse transit time (PTT). Furthermore, some advanced signal processing algorithms used in artifact management can induce unwanted errors in the timing characteristics of the recovered signals. In order to extract useful timing information, an independent component analysis algorithm based on the minimization of mutual information approach is used to post-process artifact-induced signals used in PTT computations. Experimental results from two unregulated movements demonstrated the efficacy of the proposed method in computing PTT measurements.