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Bladder cancer diagnosis with fluorescence guided spectral domain optical coherence tomography in a rat model

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4 Author(s)
Wang, Z.G. ; SUNY at Stony Brook, Stony Brook ; Hasan, M. ; Liu, J.X. ; Pan, Y.T.

A fluorescence-image-guided spectral domain OCT (FG-SDOCT) system is described. With the recent development of spectral domain OCT, the new system is able to visualize morphological details of urinary bladder with high image fidelity (e.g., 10um/12um axial/lateral resolutions, >110dB dynamic range) at 4~8-fold improved frame rate. Ex vivo study based on an AY-27 rat cancer model was performed to evaluate its ability to enhance the sensitivity and specificity. Total 82 specimens were examined by hyperisin-induced fluorescence imaging, OCT and histological microscopy sequentially. The preliminary results demonstrate the sensitivity and specificity of FG-SDOCT is 100% and 90% respectively, compared to 85% and 49% for fluorescence imaging. This significant improvement indicates that FG-OCT is a very promising technique for effective early bladder cancer diagnosis in combination of endoscopic OCT.

Published in:

Bioengineering Conference, 2007. NEBC '07. IEEE 33rd Annual Northeast

Date of Conference:

10-11 March 2007