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In order to solve the problem that scheme design parameters are various, the relationships among parameters are complicated and design knowledge acquisition is difficult, the process and mathematics expression of scheme design is analyzed. Then a method of association knowledge discovery is put forward, in which design attributes are taken as item sets, associated relationship among them are taken as analyzing target and domain knowledge is taken as constraint to control mining process. The expression and application of domain knowledge is investigated. A case study is given to illustrate that the method proposed is valid and practicable and the research has an important significance for the reuse design knowledge and design cases.