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Ultra-wideband imaging for medical applications has been of interest for many years due to its high resolution and capability of detection and classification. In this paper, ultra-wideband near-field imaging is applied for detection of small malignant tumors inside breasts. Multiple antenna and focusing algorithm are used to form a spatial image of reflectivity, and to identify the presence and location of malignant lesions from their scattering signatures. The method is demonstrated by successful detection of a 2 mm diameter tumor in a three-dimensional numerical breast model.