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Wireless intelligent sensing devices implanted in animals or in humans have rigorous size, power, functional, and reliability requirements. Miniaturized electronics integrated in part or in whole, is necessary to achieve these goals. Electronic design considerations, often unique to implants, takes into account the medical application, transducer technology, telemetry, and level of integration. In this paper, we discuss the salient issues most commonly encountered in designing mixed-signal integrated electronics for wireless implantable sensing devices. Our goal is to develop a general electronics platform that may be readily applied to many types of transducer technologies with little or no modification to the core platform. Two case studies are analyzed.