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This paper present a novel approach which allows to perform - to our knowledge for the first time - the effective optimization of entire CAD derived devices, embedded in complex environments. The new optimizer combines the advantages of genetic algorithms with the unique and superior speed of FDTD hardware acceleration. On the basis of a commercial mobile phone, the applied methods are outlined and demonstrated whereas the devices' antenna is optimized with respect to return loss/matching in free space and under real usage conditions, i.e., with head and hand. In addition, our optimization technique runs a sensitivity study for each optimized parameter in parallel.