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Multipath propagation can significantly impair performance of DS CDMA due to presence of the odd correlations of user signatures caused by delayed replicas of the transmitted signal. Traditionally to neutralize this effect some form of equalizing is used, which, along with receiver complication, leads to SNR loss. In the paper signature-interleaved (SI) DS CDMA is proposed and analyzed in application to a multipath channel. It is shown that with signature interleaving the output of a single user correlator contains only correlations of either non-shifted at all or just one-chip-shifted signatures. Thereby a deteriorating impact of odd correlations on the system performance is drastically reduced. As a result, SI DS CDMA provides performance improvement versus conventional DS CDMA with no need in complex equalizing.