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An infrastructure relay system that transfers information from a base station to a randomly located mobile station (MS) using fixed-location relay stations (RSs) is studied. Transmission rates are derived for serial, parallel, and hybrid relay transmissions, considering the utilization of RSs as a means to extend the dimensionality of a multiple-input-multiple-output (MIMO) transmission. The derived transmission rate for the serial relay transmission is optimized by determining the optimal locations of the RSs and the number of hops. In addition, selection schemes for determining which RSs to activate to maximize the transmission rate are provided for parallel and hybrid relay topologies. Based on the analytic findings, numerical results are obtained for various deployment scenarios to compare and evaluate different relay topologies and design characteristics of a relay system.