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Effect of Inhibition of Water-Soluble Propolis Extracts (WSPE) on biomolecules Damage Induced by Peroxynitrte

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4 Author(s)
Yunjing Luo ; Beijing Univ. of Technol., Beijing ; Liya Liu ; Ping Gong ; Rugang Zhong

Peroxynitrite (ONOO-) is a cytotoxicant with strong oxidizing and nitrating properties toward various biomolecules, including amino acids, DNA, lipids and proteins, thus can cause cell death, carcinogenesis or aging. The aim of this study was to investigate whether water-soluble propolis extracts (WSPE) could scavenge peroxynitre and further inhibit peroxynitrite-mediated tyrosine nitration, DNA strand breaks and low density lipoprotein (LDL) oxidation. The results show that WSPE have a strong ability to scavenge ONOO-, and its inhibition on ONOO- exhibited a concentration-dependent manner. It is suggested that propolis extracts might be developed as an effective peroxynitrite inhibitor for the prevention of ONOO- involved diseases.

Published in:

Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on

Date of Conference:

23-27 May 2007