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To develop an extended model of human cardiovascular system which is combined with the control functions of central nervous system (CNS). A multi-element, nonlinear mathematical model of the baroreflex function of CNS to the circulation model is developed . Computer simulation studies are performed and in accordance with the results of parallel human experiments and some clinical data published before. The developed model was helpful to describe the influences of CNS to the circulation system, and matched with the human system closely.