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A phenomenal growth in the mobile communication sector and ever increasing demand for multimedia information has lead to video streaming over mobile network. Upcoming 3rd generation networks, like CDMA-2000, provide high speed for transmission, allowing users have more online services. When video is used in mobile networks, the most important requirements are related to low bit-rates, frame-rates and the screen size of mobile device, along with usual bandwidth, delay and jitter requirements, especially when considering background traffic. While in wired network the quality of service (QoS) is sustainable, in wireless network, however, the error prone nature restricts the QoS. In this paper we investigated and compared the performance of upcoming video codec, H.264 with MPEG-4, when used in video transmission in mobile networks using non-acknowledgment (NAK) based radio link protocol (RLP). The results showed that the H.264 codec produced the most satisfying video quality.