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The artificial immune network (AIN), which is a new computational intelligence model based on artificial immune systems inspired by the vertebrate immune system, has been widely utilized for pattern recognition and data analysis. However, due to the inherent complexity of current AIN models, their application to remote-sensing image classification has been rather limited. This paper presents a novel supervised classification algorithm based on a multiple-valued immune network, which is a novel AIN model, to perform remote-sensing image classification. The proposed method trains the immune network using the samples of regions of interest and obtains an immune network with memory to classify the remote-sensing imagery. Two experiments with different types of images are performed to evaluate the performance of the proposed algorithm in comparison with other traditional image classification algorithms: Parallelepiped, Minimum Distance, Maximum Likelihood, and Back-Propagation Neural Network. The results evince that the proposed algorithm consistently outperforms the traditional algorithms in all the experiments and, hence, provides an effective option for processing remote-sensing imagery.