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Spatiotemporal Analysis of an Agent-Based Model of a Colony of Keratinocytes: A First Approach for the Development of Validation Methods

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3 Author(s)
Pichardo-Almarza, C. ; Sheffield Univ., Sheffield ; Smallwood, R. ; Billings, S.A.

Agent-based models are widely used for the simulation of systems from several domains (biology, economics, meteorology, etc). In biology agent-based models are very useful for predicting the social behaviour of systems; in particular they seem well adapted to model the behaviour of a cell population. In this paper an agent-based model, developed to study normal human keratinocytes (tissue cells), will be investigated. This kind of model exhibits probabilistic behaviour and the validation of simulation results is often done with a qualitative analysis by the experts (biologists). The main objective of this paper is to propose new variables and metrics that allow the comparison and a possible quantitative validation using numerical results from simulations.

Published in:

Bioinformatics and Bioengineering, 2007. BIBE 2007. Proceedings of the 7th IEEE International Conference on

Date of Conference:

14-17 Oct. 2007