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The presence and availability of several independent wired and wireless networks within a communication environment has led to the channel adaptive multiple I/O (CAMIO) protocol being developed as an appropriate and novel technique for data transmission. The proposed system utilises an intelligent multiplexing technique that enables the transmission/reception of multiple data sources via several wired/wireless networks simultaneously. Real-time configuration and adaptation capabilities when data sources/channels are dynamically added/deleted/modified are described. Data prioritisation methods, combined with traffic control and congestion-reactive techniques, are presented. Simulation results demonstrate that the use of the CAMIO protocol over multiple transmission/reception channels increases the overall data transmission rate, handles the delivery of time-sensitive packets and maintains the quality of service, especially in situations where one or more communication channels fail to operate.