By Topic

Detection of Receptor-Ligand Interactions With an GHz Impedance Biosensor System

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Schlecht, U. ; Center of Adv. Eur. Studies & Res., Bonn ; Gronewold, T.M.A. ; Malave, A. ; Tewes, M.

Nanogap impedance biosensors with an electrode separation of 75 nm have been used for the specific detection of biological interactions. Different model systems, such as thrombin-anti-thrombin antibody, and Rev-peptide-anti-Rev aptamer are presented to demonstrate the detectability of different molecular masses at varying concentrations. In order to improve the signal-to-noise ratio, the use of reference sensors has been explored. The interaction of prostate specific antigen (PSA) with an anti-PSA antibody is shown to demonstrate the detection at concentrations as low as 10 nM.

Published in:

Sensors Journal, IEEE  (Volume:7 ,  Issue: 12 )