By Topic

Modeling G-Protein Induced Protein Kinase C Activation Cascade: Deterministic and Stochastic Simulations

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Eeva Makiraatikka ; Institute of Signal Processing, Tampere University of Technology, P.O. Box 553, FI-33101 Tampere, Finland. ; Antti Saarinen ; Olli Yli-Harja ; Marja-Leena Linne

Despite the transient phenomenon of activation of G-pro-tein by primary messengers on the plasma membrane, the protein kinase C (PKC) gets activated via the amplified signaling cascade stimulated by G-protein. The second messengers activating PKC play a vital role in this cascade. Therefore it is important to mimic their behavior in the model, where the activation of the G-protein initiates the liberation of second messengers. Due to the volume of the biological system under study, the signaling pathway is simulated also with stochastic algorithm. The work will contribute to understanding and describing complex cellular phenomena by taking better into account the existing experimental knowledge on the liberation of second messengers more as burstlike quantities rather than as constant flows.

Published in:

2007 IEEE International Workshop on Genomic Signal Processing and Statistics

Date of Conference:

10-12 June 2007