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Accurate, computationally intensive numerical algorithms have become necessary to handle the increasing complexity of electromagnetic problems in biological applications. In this work, a high performance hybrid- MoM/FDTD approach is presented for electromagnetic analysis and design applications in microwave breast tumor detection. The proposed algorithm is based on Huygen's equivalent surface methods. The simulation study of a bow-tie antenna-breast phantom interaction demonstrates the efficacy of the proposed algorithm and suggests that, with further development, this hybrid scheme would be a useful tool in the continued development of microwave imaging for breast cancer.