Cart (Loading....) | Create Account
Close category search window
 

Patterned Optical Activation of Retinal Ganglion Cells

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Farah, N. ; Technion - Israel Inst. of Technol., Haifa ; Reutsky, I. ; Shoham, S.

Neuroprosthetic retinal interfaces depend upon the ability to bypass the damaged photoreceptor layer and directly activate populations of retinal ganglion cells (RGCs). To date, the preferred approach to this task largely relies on electrode array implants. We are currently pursuing two alternative methods for light-based direct activation of the RGCs. The first method is based on applying caged glutamate over the retina and uncaging it locally to obtain RGC excitation. The second method is to artificially cause RGCs to express Channelrhodopsin II (ChR2), a light-gated cation channel. In addition to being non-contact, optical techniques lend themselves relatively easily to a variety of technologies for achieving patterned stimulation with high temporal and spatial resolution. Using the Texas Instruments Digital Light Processing (DLP - DMD) technology, we have developed an optical stimulation system capable of controlled, large-scale, flexible stimulation of the retinal tissue with high temporal accuracy. In preliminary studies, we are performing patterned photo-stimulation experiments using samples of caged fluorescent probes and in rat retinas that were virally transfected with ChR2.

Published in:

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE

Date of Conference:

22-26 Aug. 2007

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.