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The biomedical environment is one of the most recent and interesting application fields for CMOS image sensors. Low power consumption, high sensitivity and a simple interface are the main required features; nevertheless high dynamic range can be considered one of the more interesting and less investigated aspects. High Dynamic range is one of the main research fields NeuriCam has been involved in since its incipit. This work is an excursus of NeuriCam's approaches to this topic.