By Topic

Voxelized Model of Interstitial Transport in Nervous Tissue Following Direct Infusion into White Matter

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Jung Hwan Kim ; Department of Mechanical & Aerospace Engineering, University of Florida, Gainesville, FL 32611. e-mail: junghwan@ufl.edu ; Thomas H. Mareci ; Malisa Sarntinoranont

Direct infusion of therapeutic agents into the brain and spinal cord is a promising local delivery method that circumvents the blood-brain barrier and blood-spinal cord barriers. Predictive models of interstitial (extracellular) distribution during direct infusion would be useful in treatment optimization and planning. To account for large infusion volumes, such models should incorporate tissue boundaries and anisotropic tissue properties. We have developed a rapid, semi-automatic computational modeling approach that utilizes diffusion tensor imaging data to predict interstitial tissue distributions of injected tracers. The developed methodology was validated for direct infusion into the dorsal white matter column of the rat spinal cord.

Published in:

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Date of Conference:

22-26 Aug. 2007