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Neuroimaging studies involved acupuncture have already demonstrated its significant modulatory effects on the limbic system, paralimbic and subcortical gray structures. These structures with presumably intimated relationships with acupuncture may constitute a network. In this study, we employed a network mode from the graph theory to evaluate the functional connectivity among multiple brain regions in the resting brain. Evidence from our findings clearly supported the existence of a large functional connectivity network constructed during a resting condition with fMRI. We concluded that acupuncture stimulation may induce the modulation of the 'acupuncture-related' network to exert its influence on the therapeutic effects, presented by significant changes of functional connectivity of some brain regions. Our study may provide a further step to the exploration of the underlying mechanism of acupuncture effects.