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The purpose of this paper is to report the integration studies of business modeling and roadmapping methods for "innovation support technology (IST)" and IST's practical application to real-world-cases. IST is conducted for the purpose of offering a convenient tool for engineers and researchers in order to enhance corporate value from R&D outputs. "Japan's lost decade" has forced companies to change R&D management and R&D operation style, especially regional industries. We propose the framework for revitalization of regional industries by using the strategic technology roadmap made by the Ministry of Economy, Trade and Industry (METI-TRM) with business modeling. We applied this method IST to several real-world-cases to show its effectiveness. This study represents the result of over four years (fall 2002) of work with the value creation framework of business modeling method for R&D outputs, done by a group of researchers from JATES (Japan Techno-Economics Society).