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In this paper, an ant colony optimization (ACO) based ant crew scheduling model (ACSM) is proposed to solve airline crew scheduling problems. In the proposed ACSM, airline crew scheduling problems are first formulated as traveling salesman problems with flight graph representation. Then, the ACO algorithm is applied to search near-optimal solutions for airline crew schedules. The validity of the proposed ACSM is verified by implementing it in real study cases. The results from the implementation and evaluation confirm that the proposed ACSM is suitable for the airline crew scheduling problems with good performance.