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This case study focuses on a massively parallel multiprocessor for real-time simulation of billions of neurons. Every node of the design comprises 20 ARM9 cores, a memory interface, a multicast router, and two NoC structures for communicating between internal cores and the environment. The NoCs are asynchronous; the cores and RAM interfaces are synchronous. This GALS approach decouples clocking concerns for different parts of the die, leading to greater power efficiency.