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A Statistical Analysis of Count Normalization Methods Used in Positron-Emission Tomography

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3 Author(s)
Holmes, Timothy J. ; Institute for Biomedical Computing, Department of Electrical Engineering, and Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110 ; Snyder, Donald L. ; Ficke, David C.

As part of the Positron-Emission Tomography (PET) [1] reconstruction process, annihilation counts are normalized for photon absorption, detector efficiency and detector-pair duty-cycle. Several normalization methods of time-of-flight and conventional systems are analyzed mathematically for count bias and variance. The results of the study have some implications on hardware and software complexity and on image noise and distortion.

Published in:

Nuclear Science, IEEE Transactions on  (Volume:31 ,  Issue: 1 )

Date of Publication:

Feb. 1984

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