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Interface designs for three nuclear medicine imaging systems, and computer networking strategies proposed for medical imaging departments are presented. Configurations for two positron emission tomography devices (PET III and ECAT) and a general purpose tomography instrument (the UNICON) are analyzed in terms of specific performance parameters. Interface designs for these machines are contrasted in terms of utilization of standard versus custom modules, cost, and ease of modification, upgrade, and support. The requirements of general purpose systems for medical image analysis, display, and archiving, are considered, and a realizable state of the art system is specified, including a suggested timetable.