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A portable system for the measurement of cerebral blood flow in critical care environments such as the intensive care unit or operating room has been developed and tested in a limited series of patients. The flow measurements are based on the 133Xe inhalation or IV injection method. The system uses miniature solid state detectors, microprocessor technology and Fourier transform based data analysis to provide compactness and rapid on-line analysis of data. Preliminary patient studies comparing this system with a larger sodium iodide detector system show comparable results.