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During the past several years, we have developed dedicated digital algorithms for real time processing of X-ray transmission imaging data obtained from an image intensifier television fluoroscopy system. Three imaging modes called Mask Mode Fluoroscopy, Mask Mode Radiography, and Time Interval Difference (T. I. D.) Imaging have been tested in over 100 patients since installation of this. apparatus at the University of Wisconsin Clinical Science Center. Feasibility studies have been conducted to determine the capability of these techniques for imaging the entire cardiovascular system, including peripheral arteries, using intravenous injections of iodinated contrast material.