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Fluorescence Bronchoscope for Lung Tumor Localization

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3 Author(s)
Profio, A.Edward ; University of California Santa Barbara, CA 93106 ; Doiron, Daniel R. ; Huth, Gerald C.

A fluorescence bronchoscope has been developed for localization of small bronchogenic tumors at the carcinoma in situ stage. Injected hematoporphyrin-derivative is preferentially taken up or retained by a malignant tumor, and very small amounts can be detected by the red fluorescence under excitation by violet light. The target lesion is 80 ¿m thick, with a mass of 250 ¿g, containing 250 pg of hematoporphyrin-derivative. A fiberoptic bronchoscope system with a 200W high pressure mercury arc lamp, primary filter passing 405 nm light, special violet transmitting light conductor, coherent imaging bundle, red secondary filter, and three-stage electrostatic focus image intensifier tube was designed for this application. Tumors have been visualized in animals and preparations for clinical use are underway.

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Nuclear Science, IEEE Transactions on  (Volume:24 ,  Issue: 1 )