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MOSFET devices and microcircuits have been designed and built into flight hardware for use in open operational spacecraft (IMP D&E) by NASA/GSFC. A look at some of the engineering results associated with studying this class of devices for use in these applications is reviewed here. In addition, there is a first-cut engineering study for comparison of performance, in a simulated space radiation environment, of two types of MOSFET's and the newer experimental silicon nitrite devices (MNS-FET). The experiments reported upon are application parameter oriented and of limited sample size. Therefore, no attempt is made to draw any far-reaching conclusions about MOSFET's in general, nor are any devices physics oriented interpretations included.