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For the first time, we demonstrate organic transistor-based DNA sensors. DNA molecules are immobilized directly on the surface of organic semiconductors, producing an unambiguous doping-induced threshold voltage shift. With these shifts, single- and double stranded DNA are differentiated successfully. Factors that influence sensor sensitivity have been analyzed and optimum conditions have been determined using statistically designed experiments. In order to make DNA detection fast, we also demonstrate sub-millisecond on-chip electrically enhanced hybridization using the transistors. These technologies together enable the realization of disposable, rapid-turnaround tools for field-deployable genomic diagnosis.