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Wireless environments are typically characterized by unpredictable and unreliable channel conditions. In such environments, fragmentation of network-bound data is a commonly adapted technique to improve the probability of successful data transmissions and reduce the energy overheads incurred due to re-transmissions. The overall latencies involved with fragmentation and consequent re-assembly of fragments are often neglected which bear significant effects on the real-time guarantees of the participating applications. This work studies the latencies introduced as a result of the fragmentation performed at the link layer (MAC layer in IEEE 802.11) of the source device and their effects on end-to-end delay constraints of mobile applications (e.g., media streaming). Based on the observed effects, this work proposes a feedback-based adaptive approach that chooses an optimal fragment size to (a) satisfy end-to-end delay requirements of the distributed application and (b) minimize the energy consumption of the source device by increasing the probability of successful transmissions, thereby reducing re-transmissions and their associated costs.