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The self-interference (SI), which is caused by imperfect channel estimation, and co-channel interference (CCI) are considered in multiple-input multiple-output systems employing maximal ratio combining under independent and identically distributed Rayleigh fading. The analysis is independent of any specified estimation scheme and the channel estimation errors are assumed to be Gaussian distributed. Closed-form expressions for cumulative distribution function of the output signal-to-interference plus noise ratio are derived for both equal-power and unequal- power CCI cases. On the basis of these expressions, the exact closed-form expressions for the symbol error rate are presented to investigate the impact of SI and CCI. The analytical results are compared with the simulation results and a good agreement is obtained.