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Moisture is one of the major contributing factors in fracture and reliability issues for microelectronic packaging. To characterize the moisture-induced stress distribution inside the packaging structure, an in situ, quantitative, and nondestructive experimental methodology is needed. This paper proposes the use of piezoresistive sensors to measure moisture-induced stress in a plastic low profile, fine pitch, ball grid array (LFBGA) packaging. The measurements include hygroscopic swelling stress extractions and real-time stress monitoring of the popcorn phenomenon, and the results associated with gravimetric analyses are reported. Postreflow scanning acoustic microscope (SAM) inspection results and cross section observations are used as experimental verification. Comparing with thermal stresses previously measured on the same package, it is found that the hygroscopic mismatch stress is significant and important for package engineers. In addition, piezoresistive sensors were proven useful in this work for recording popcorn occurrence and monitoring the stress drops at the popcorn initiation.