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Evaluation of Cell Velocity Regulation in a Microfabricated Adhesion-Based Cell Separation Device

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3 Author(s)
Miwa, J. ; Dept. of Mech. Eng., Tokyo Univ. ; Suzuki, Y. ; Kasagi, N.

This paper reports the characterization of adhesion-based cell velocity regulation in a prototype microfabricated cell separation device for regenerative medicine. The principle of cell sorting is based on immunoreaction for accurate recognition of target stem cells. Target-cell specific antibody is immobilized on the micro channel wall to form a selectively adhesive surface, where a new class of functionalized parylene is used as the surface material for antibody immobilization. The flowing velocity of sample cells in a prototype microfabricated cell separation column is examined under the microscope. The measurement results show that the cell velocity is reduced by 40% due to the effect of antigen/antibody interaction

Published in:

Microtechnologies in Medicine and Biology, 2006 International Conference on

Date of Conference:

9-12 May 2006