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Microfluidic Valve Employing the pH-Responsive Hydrogel Microsphere as an Actuating Element

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6 Author(s)
Ji Young Park ; Department of Biomedical Engineering, College of Medicine, Korea University, Korea; Korea Artificial Organ Center, Korea University, Korea; Department of Biomedical Engineering, DanKook University, Korea; Korea Artificial Organ Center, Korea University 126-1, Anam-dong 5ga, Seongbuk-gu, Seoul 136-705, Korea. Tel +82-2-920-6457, Fax +82-2-920-4204, E-mail ; Duck Joong Kim ; Sung Rak Kim ; Ju Yeoul Baek
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In this paper, we propose a new fabrication method of pH-responsive microfluidic valves and suggest the feasibility as a microminiature systems without peripheral devices. Conventionally, in-situ photopolymerization method has been employed to build the micro functional structure inside microfluidic channel. Here, we suggest a new method allowing the mass production of stimuli-responsive microsystem through the use of pre-made microstructure as actuating element like assembly of commercial products in the factory. We have massively fabricated pH-responsive microspheres that act as actuating component through the use of PDMS-based microfluidic apparatus and 'on the fly' photopolymerization method. By the incorporation of this microsphere into the microvalve during the fabrication process, we have produced the pH-responsive microfluidic valve in a simple way. The operation and the function of the fabricated microvalve were evaluated through the diverse experiments. The microvalve was successfully fabricated, and functioned well according to the pH change

Published in:

Microtechnologies in Medicine and Biology, 2006 International Conference on

Date of Conference:

9-12 May 2006