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To better understand the process of CO2 laser tissue ablation, a dynamic model was proposed, which consisted of (1) calculations of temperature distribution using finite difference heat transfer model and thermal damage distribution using Arrhenius equation, (2) a procedure of dividing laser-irradiated tissue into multi-zones according to the temperature and thermal damage distribution, and (3) calculations of variable parameters of each zone. Simulations were performed with a laser power of 10 W/mm2. Evolutions of the surface temperature and each zone were obtained. The results of this study indicate our model is a powerful tool for improving the understandings of laser tissue ablation.