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A Study on DNA Damage of Rat Brain Cells Induced by Formaldehyde

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4 Author(s)
Zhou Yanqing ; Lab. of Environ. Sci. Coll. of Life Sci., Huazhong Normal Univ., Wuhan ; Wang Kun ; Zhou Esheng ; Yang Xu

Objective: To explore the DNA damage of brain cells of rat after formaldehyde exposure. Methods: Rat brain cells were exposed to different concentrations of liquid formaldehyde (0.005, 0.025, 0.125 and 0.625 mmol/L) for lh. Single cell gel electrophoresis technique (comet assay) was used to test the DNA damage of the brain cells. Result: Formaldehyde could significantly cause DNA strands breakage at concentrations of 0.005 and 0.025 mmol/L while crosslinks were induced at concentrations of 0.125 and 0.625 mmol/L. Conclusions: Formaldehyde is the both a DNA strands breaker and crosslink agent to the brain in vivo.

Published in:

Bioinformatics and Biomedical Engineering, 2007. ICBBE 2007. The 1st International Conference on

Date of Conference:

6-8 July 2007