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Localized closed-loop temperature control and regulation in hybrid silicon/silicone life science microsystems

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3 Author(s)
Jennifer Blain Christen ; Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21218 USA. Email: blain@jhu.edu ; Andreas G. Andreou ; Brian Iglehart

We present hybrid silicon/silicone microsystem for closed-loop temperature control with applications in the life sciences. The system architecture includes an integrated CMOS die for localized thermal cycling and a disposable PDMS microfluidic structure for aseptic fluidic manipulation. Chip design, experimental results and finite element analysis are presented. This work is based on criteria for a clinical diagnostics system comprised of disposable microfluidics for use in tandem with CMOS electronics.

Published in:

2007 IEEE International Symposium on Circuits and Systems

Date of Conference:

27-30 May 2007