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This article describes a methodology for establishing a general framework of the information management and aided decision making system for earthquake disaster reduction by means of a WebGIS. The system has a three-tier architecture consisting of data service, middleware, and expression service tiers. The system database is composed of the seismogeological database, the engineering environmental database, the disaster relief resource database and the analysis result database. The function components in the middleware tier include the earthquake hazard analysis, the construction vulnerability estimation, the quantifying economic losses and casualties caused by earthquakes, and the aided decision making components for post-earthquake emergency response. In order to further analyze earthquake damage data, three WebGIS analysis modules are designed on the client side, namely the foundational information module, the earthquake loss module and the emergency response module. In the information system based on this framework, the information about earthquake disaster reduction can be shared, the earthquake disaster data can be all-around analyzed, and aided decision making for post-earthquake emergency response can be efficiently made.