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A novel microstrip lowpass filter utilizing defected ground structure (DGS) units is presented in this paper. A DGS unit is simulated with different physical dimensions in order to show variation of effective inductance and capacitance. Next, a lowpass filter using proposed DGS unit is designed. A method for determining dimensions of microstrip structure and DGS units is proposed. Influence of dimensions of the microstrip structure on filter characteristics is investigated and simulated. Filters of various orders are simulated as well. Selected filter is simulated and experimentally verified.