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This paper presents a methodology to compute the distortion output of a class of third-order nonlinear dynamic systems from only standard two-tone test results. Closed-form expressions are presented to compute the distortion output and metrics as adjacent channel power ratio and co-channel power ratio/noise power ratio for an arbitrary multisine with N tones. The impact of memory effects in a multisine excitation is also addressed, improving the design of RF components by a careful understanding of memory effects mechanism in real modulated signals. An experimental validation is presented to prove the proposed theory.