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The next decades will see an explosion in the use and the scope of medical imaging, fueled by advanced computing and visualization techniques. In my opinion, advanced, multimodal imaging and visualization techniques, powered by new computational methods, will change the face of biology and medicine and provide comprehensive views of the human body in progressively greater depth and detail. As the resolution of imaging devices continue to increase, image sizes grow accordingly. Multi-modal and/or longitudinal imaging studies result in large-scale data sets requiring parallel computing and visualization. In this presentation, I will discuss the state-of-the-art in large-scale biomedical imaging and visualization research, present examples of their vital roles in neuroscience, neurosurgery, radiology, and biology and discuss future challenges.