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MIMO-based systems have great potential to improve network capacity for wireless mesh networks (WMNs). Due to unique physical layer characteristics associated with MIMO systems, network performance is tightly coupled with mechanisms at physical layer and link layer. So far, research on MIMO-based WMNs is still in its infancy and little results are available in this important area. In this paper, we consider the problem of jointly optimizing power and bandwidth allocation at each node and multihop/multipath routing in a MIMO-based WMN where links operate in orthogonal channels. To solve this problem, we develop a mathematical solution procedure, which combines Lagrangian dual decomposition, gradient projection, and cutting-plane methods. We provide theoretical insights in deriving gradient projection and cutting plane methods. We also use simulations to verify the efficacy of our algorithm.