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A Benchtop System to Assess Cortical Neural Interface Micromechanics

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5 Author(s)
R. Das ; Dept. of Bioeng., Illinois Univ., Chicago, IL ; D. Gandhi ; S. Krishnan ; L. Saggere
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A benchtop brain tissue-microelectrode insertion model system was developed to aid in improving the design of cortical neural interfaces. The model partially mimics the in vivo environment via the use of human cadaver brain specimens (nspecimen=6), or agar gel exposed to physiologically relevant mechanical oscillations. 150 mum diameter stainless-steel microelectrode wires (TS=600 MPa) implanted 3.0 cm within fixed human primary auditory cortex (ntrial>10) experienced 133plusmn8 and 64plusmn4 mN of peak and steady axial forces. When subjected to a 3 Hz, 3-mm vertical oscillation, dynamic force amplitudes (ntrial>10) of 148plusmn10 mN were measured. The model system allows the study and comparison of static and dynamic forces and their mechanical influences on proposed implanted microelectrode structures

Published in:

IEEE Transactions on Biomedical Engineering  (Volume:54 ,  Issue: 6 )