Referenced Items are not available for this document.
We report a simplified single emulsion (oil-in-water) solvent evaporation protocol to synthesize surface functionalized biocompatible magnetic nanospheres by using highly concentrated hydrophobic magnetite (gel) and a mixture of poly(D,L lactide-co-glycolide) (PLGA) and poly(lactic acid-block-polyethylene glycol-maleimide) (PLA-PEG-maleimide) (10:1 by mass) polymers. The as-synthesized particles are approximately spherical with an average diameter of 360-370 nm with polydispersity index of 0.12-0.18, are surface-functionalized with maleimide groups, and have saturation magnetization values of 25-40 emu/g. The efficiency of the heating induced by 400-kHz oscillating magnetic fields is compared for two samples with different magnetite loadings. Results show that these nanospheres have the potential to provide an efficient cancer-targeted hyperthermia.
Published in:
Magnetics, IEEE Transactions on
(Volume:43
,
Issue:
6
)
Date of Publication: June 2007
- Page(s):
- 2462 - 2464
- ISSN :
- 0018-9464
- INSPEC Accession Number:
- 9555991
- Digital Object Identifier :
- 10.1109/TMAG.2007.894004
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 21 May 2007
- Issue Date :
- June 2007
- Sponsored by :
- IEEE Magnetics Society
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