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This paper deals with a wearable sensor platform for future exploration in space called Bio-Life. It is based on a network of integrated fabric sensors and advanced signal processing techniques, that gathers various parameters such as ECG, pulse oximetry, temperature, and other biomedical signals. They are process using fuzzy logic or neural networks. Primary design considerations include astronaut monitoring, safety, comfort and donning. This system is designed to be embedded in Bio-Suit, a revolutionary space suit concept developed for many years by Prof. Dava Newman and her team from MIT in collaboration with the NASA Institute for Advanced Concepts (NIAC).